出版日期：2025-11-26 00:00:00

著者：Tzu-Wei Huang; Chih-Yang Lai; Po-Ju Lai; Rifky Rahardian Setiawan; Chao-Tsai Huang; Yi-Hua Kuo; Shih-Jung Liu

著錄名稱、卷期、頁數：International Polymer Processing

摘要：Traditional fabrication methods for delivery vehicles often rely on thermal or solvent processing, which can pose challenges for heat- and solvent-sensitive bioactive molecules, such as proteins and peptides. These molecules may denature or lose their biological activity, ultimately reducing their therapeutic efficacy. This study proposed a simple and versatile biodegradable perforated capsule for sustained delivery of bioactive molecules. Poly (lactic-coglycolic acid) (PLGA) capsules with side perforations were fabricated using a compressionmolding method. Teicoplanin, mixedwith either phosphate-buffered solution, Pluronic F-127 hydrogel, or hyaluronic acid, was then filled into the core of the capsules. The in vitro release rates of teicoplanin were characterized over a 30-day period using an elution method and a high performance liquid chromatography (HPLC) assay. The experimental results demonstrated that the biodegradable perforated capsules released high concentrations of teicoplanin, exceeding the minimum inhibitory concentration (MIC), in vitro for 30 days. Furthermore, the high viscosity of the Pluronic F-127 hydrogel and hyaluronic acid prolonged the antibiotic’s release period. This novel capsule design holds significant promise for delivering active biomolecules, including drugs, proteins, and peptides, for long-term therapeutic applications.

關鍵字：perforated capsule;polylactide-polyglycolide;teicoplanin;release profiles

語言：en

期刊性質：國外

收錄於：SCI

通訊作者：Shih-Jung Liu

審稿制度：否

國別：DEU

出版型式：電子版,紙本