出版日期：2019-01-02 00:00:00

著者：Chih-Yu Kuo; Trong-Ming Don; Yen-Ting Lin; Shih-Chi Hsu; Wen-Yen Chiu

著錄名稱、卷期、頁數：Journal of Polymer Research 26(1), Article:18

摘要：Sulfonamide-containing linear copolymers were synthesized via copolymerization of N-(4-methacrylamido)-N′-(4,6-dimethylpyrimidin-2-yl) benzene-1-sulfonamide (SAM) and N,N′-dimethylacrylamide (DMAAm) via free-radical polymerization at room temperature using redox initiators. The redox-initiated polymerization could undergo nearly complete reaction in which the copolymer composition was almost the same as the feeding monomer ratio. These linear copolymers could be dissolved in water and displayed pH-sensitive properties around the physiological pH value of human body with a very sharp transition window less than 0.1 pH unit. Moreover, by introducing N-methyloyl acrylamide (NMA) monomer into the reaction system, the resulting copolymers could become crosslinked hydrogels when subjected to post thermo-curing through the NMA units. The crosslinking density and pH-sensitivity could be manipulated by changing the curing time and temperature. Therefore, swelling ratio and gel fraction of hydrogels could be accurately tailored. The pH-sensitive windows of these hydrogels were found to maintain in between 6.80 to 7.40, which implied that these hydrogels would be a suitable candidate for biomedical materials.

關鍵字：Sulfonamidemonomer;Hydrogels;pH-sensitive;Swelling ratio;Crosslinking

語言：en_US

ISSN：1022-9760

期刊性質：國外

收錄於：SCI EI

通訊作者：Trong-Ming Don

審稿制度：是

國別：NLD

出版型式：電子版,紙本