出版日期：2022-10-26 00:00:00

著者：Kuo-Chung Cheng; Chia-Chien Hu; Chih-Ying Li; Shih-Chi Li; Zhi-Wei Cai; Yang Wei; Trong-Ming Don

著錄名稱、卷期、頁數：Polymers 14(21), 4538

摘要：Pectin/chitosan hydrochloride (CHC) particles containing theophylline were prepared by a spray-drying apparatus coupled with a continuous feeding ultrasonic atomizer and a heating column. The formation of the submicron particles was investigated at various compositions of pectin solutions added with a chitosan hydrochloride or calcium chloride solution as a crosslinking agent. Scanning electron microscopic (SEM) images showed the pectin/chitosan hydrochloride particles had spherical and smooth surfaces. Depending on the feeding concentrations, the produced particles had diameters in the range of 300 to 800 nm with a narrow size distribution. Furthermore, the theophylline (TH)-loaded pectin/CHC particles were also prepared by the same apparatus. The TH release from the submicron particles in phosphate-buffered saline at 37 °C was monitored in real-time by a UV-Visible spectrophotometer. The Ritger–Peppas model could well describe the TH release profiles. All the diffusional exponents (n) of the release systems were greater than 0.7; thus, the transport mechanism was not a simple Fickian diffusion. Particularly, the n value was 1.14 for the TH-loaded particles at a pectin/CHC weight ratio of 5/2, which was very close to the zero-order drug delivery (n = 1). Therefore, the constant drug-release rate could be achieved by using the spray-dried pectin/CHC particles as the drug carrier.

關鍵字：pectin;chitosan hydrochloride;submicron particles;ultrasonic atomizer;spray dryer;Ritger–Peppas model;control release

語言：en

ISSN：2073-4360

期刊性質：國外

收錄於：SCI

審稿制度：是

國別：CHE

出版型式：電子版